Dr Thalia Mamas BSc, MSc, PhD – Geneticist University College London

Dr Thalia Mamas completed her undergraduate degree (Bsc) on Molecular Genetics at King’s College, University of London in 2003. She performed her first postgraduate degree at the same University entitled MSc Molecular Life Sciences Research, which she completed with Distinction in 2004. During this degree she was trained in the application of basic molecular genetic techniques as part of the dissertation, which was based on the genetics of the yeast S. cerevisiae and its use as a model organism.

Upon the completion of the MSc at King’s College she attended a second postgraduate degree at University College London (UCL), University of London, entitled: MSc in Prenatal Genetics and Fetal Medicine. The main topic of the degree was the combination of genetics and reproduction. She also attended courses on embryology, assisted reproduction and fetal medicine.

In 2005 Dr Mamas was accepted by the UCL Centre for PGD, part of UCL’s Institute for Women’s Health, to attend a PhD program. During her PhD years she was also trained in preimplantation genetic diagnosis (PGD). For seven years she worked as a member of PGD group at UCL under well known scientists of the field: Professor Joy Delhanty, Dr Joyce Harper and Dr Sioban SenGupta. She performed the development, optimisation and clinical application of PGD protocols for numerous genetic disorders. These included: inherited forms of cancer, like breast cancer and neurofibromatosis. She also developed and clinically applied array comparative genomic hybridisation (aCGH) for the diagnosis of chromosomal abnormalities in the UCL lab. Work from that field was published in the scientific journal Fertility and Sterility. Finally, during employment by the UCL Centre for PGD she actively aided the lab in being the first PGD lab in the world to receive accreditation, she attended numberous international congresses, where in most she presented her work.

Her doctoral research, which was completed in 2012, was based in embryonic aneyploidy at the preimplantation stage. More specifically, it included the development and application of aCGH, investigating the aneuploidy level of embryos from fertile and infertile couples and finally studying DNA recombination in male and female gametes.



  • Mamas T, Gordon A, Brown A, Harper J, Sengupta S. 2012. Detection of aneuploidy by array comparative genomic hybridisation using cell lines to mimic a mosaic trophectoderm biopsy. Fertil Steril. 97(4): 943-7.
  • Xantopoulou L, Delhanty JD, Mania A, Mamas T, Serhal P, Sengupta SB, Mantzouratou A. 2011. The nature and origin of binucleate cells in human preimplantation embryos: relevance to placental mesenchymal dysplasia. Reprod Biomed Online. 22(4): 362-70.
  • Kakourou G, Dhanjal S, Mamas T, Serhal P, Delhanty JD, SenGupta SB. 2010. Modification of the triplet repeat primed polymerase chain reaction method for detection of the CTG repeat expansion in myotonic dystrophy type 1: application in preimplantation genetic diagnosis. 2010. Fertil Steril. 94(5): 1674-9.
  • Kakourou G, Dhanjal S, Mamas T, Gotts S, Doshi A, Fordham K, Serhal P, Ranieri DM, Dehanty JD, Harper JC, SenGupta SB. 2008. Preimplantation genetic diagnosis for myotonic dystrophy type 1 in the UK. Neuromuscul Disord. 18(2): 131-6.
  • Dhanjal S, Kakourou G, Mamas T, Saleh N, Doshi A, Gotts S, Nuttal S, Fordham K, Serhal P, Delhanty J, Harper J, Sengupta S. 2007. Preimplantation genetic diagnosis for retinoblastoma predisposition. Br J Ophtalmol. 91(8): 1090-1.

Congress presentations

  • Mamas T, Dhanjal S, Jaroudi S, Kakourou G, SenGupta S. 2007. Preimplantation Genetic Diagnosis for inherited cancer predisposition – Different strategies. J Med Genet. 44 (Supplement 1): S69. (British Society of Human Genetics conference, York, UK).
  • Mamas T, Kakourou G, Dhanjal S, Doshi A, Gotts S, Serhal P, Delhanty J, Harper JC, Sengupta S. 2008. Detection of aneuploidy in embryos from PGD cases for single gene disorders. J Med Genet. 45 (Supplement 1): S62. (British Society of Human Genetics conference, York, UK).
  • Mamas T, Craig A, Garcia-Bernando J, SenGupta S, Gordon T, Brown A, Harper JC. 2009. Validation of single cell comparative genomic hybridisation using aneuploidy and normal cells from epithelial cell lines. (UCL Institute for Women’s Health 2nd international meeting: Innovations and progress in healthcare for women, London, UK).
  • Mamas T, Kakourou G, Dhanjal S, Cawood S, Doshi A, Serhal P, Xanthopoulou L, Mantzouratou A, Delhanty J, Harper JC, SenGupta S. 2009. Detection of chromosomal aneuploidy in embryos from preimplantation genetic diagnosis cases for monogenic disorders. Reprod Biomed Online. 18 (Supplement 3): S11. (Preimplantation Genetic Diagnosis International Society conference, Miami, USA).
  • Mamas T, SenGupta S, Dafou D, Gordon T, Harper JC. 2009. Detection of chromosomal abnormalities in single cells from epithelial cell lines by array comparative genomic hybridisation. J. Med Genet. 46 (Supplement 1): S19. (British Society of Human Genetics conference, Warwick University, UK).
  • Mamas T, Craig A, Garcia-Bernando H, SenGupta S, Gordon T, Brown A, Harper JC. 2010. Validation of single cell array comparative genomic hybridisation using aneuploidy and normal cells from epithelial cell lines. (Association of Clinical Embryologists meeting, Bristol, UK).


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