In our Centre, there is a special department for women with Premature Ovarian Failure, i.e premature menopause. Our long experience in dealing with premature menopause led us to classify women into γroups depending on the values of their FSH level. Therefore, treatment with the appropriate protocol offers excellent results.
These groups are:
Women with Premature Ovarian Failure (POF – Premature Ovarian Failure)
Following innovative and persistent research, our Centre implemented the administration of DHEA to reduce FSH in women with POF ie, women younger than 40 years of age with amenorrhea and FSH values higher than 40 – 130mIU/ml. DHEA is a naturally pro-hormone that is commercially available as a dietary supplement.
The first encouraging results of DHEA treatment were published in the medical journal Fertility and Sterility (2009) of the American Society of Reproductive Medicine. Since then, many leading IVF centers administer DHEA helping a great number of women with high FSH.
Women with Premature Ovarian Aging (POA – Premature Ovarian Aging)
A significant number of women aged 35-46 years show increased FSH level ranging from 12 to 40 mIU / ml. These women had undergone ovulation induction for IVF but with poor ovarian response and a small number of eggs. Even if the response to the ovulation induction was good, the quality of oocytes and embryos was not the best, so, in these women embryo transfer was not performed.
Our experience with the use of DHEA (Dehydroepiandrosterone) prompted us to administer DHEA to the women of this group, resulting in the decline of FSH level to 10mIU/ml. Having achieved this, we used gentle ovulation induction treatment resulting in good response in egg production and embryos that reached the blastocyst stage, thereby increasing, success of implantations and pregnancies.
Women with Diminished Ovarian Reserve (DOR – Diminished Ovarian Reserve)
Finally, treatment with DHEA was extended to women with Diminished Ovarian Reserve (DOR), which despite having normal FSH levels (<12mIU/ml), they produce a low number and poor quality oocytes following high doses of hormonal stimulation. A significant number of these women can be helped with personalized, milder ovulation induction protocols in combination with DHEA.