Ovarian and endometrial rejuvenation with PRP (Platelet Rich Plasma) for the treatment of infertility
Ovarian rejuvenation to restore fertility is a recent technology that gives hope to many women with depleted egg reserves, thin endometrium and menopause even.
The activation of platelets releases substances that are essentially healing proteins called growth factors
This platelet-rich plasma is injected into the ovaries, where the eggs are (similar to egg retrieval), under mild anesthesia with an ultrasound-guided needle. In the endometrium however the platelet-rich plasma is injected into the endometrial cavity with a catheter.
Indications for treatment of women with PRP (Platelet Rich Plasma)
• reduced ovarian reserve
• poor egg quality
• high rate of abnormal embryos
• menopause
• Thin endometrial thickness
• Miscarriages from natural conception (50%–60% due to chromosomal abnormalities)
For women who want to have children with their own eggs, and do not wish to receive donated eggs, a procedure that also has high costs.
Administration of PRP to the ovaries may improve egg quality in women who have previously had poor results with IVF.
Women with low egg reserves will especially be helped to improve the quantity and quality of their eggs and increase their chances of achieving pregnancy.
If there has been a failed IVF cycle, poor egg quality or poor embryo quality, ovarian stimulation could help and improve the chances of success in a future IVF cycle.
How is the process of rejuvenation performed? Blood is taken from the woman who is going to undergo the procedure and is subjected to a special treatment. From the blood plasma after condensation, the platelets, growth factors and stem cells are taken to be administered to the ovaries or the endometrium that we want to renew
How long does ovarian rejuvenation (PRP) take to work? For the ovaries it is 10-15 days while for the endometrium it is 3-5 days. The results of the action in the administration of PRP for the ovaries and endometrium last about 3 months.
How does platelet-rich plasma (PRD) improve IVF success? Recent studies have shown that women who previously had a high rate of abnormal embryos were 4 times more likely to have preimplantation diagnosis (PGD) normal embryos after PRP injections.
Can PRP improve AMH? If AMH (AntiMullerian Hormone) is low, then the egg supply is likely to be low. A recent study looking at women with low ovarian reserve measured changes in AMH in two groups of women, one group that had been treated with PRP and the other that had not. It was found that the group of women who received PRP treatment showed a significant improvement in AMH compared to the untreated group.
The thickness of the endometrium plays a key role, producing the nutrients for the implantation of the blastocyst and for its continued development,
Ultrasound monitoring of the thickness of the endometrium, which can reach 9-12 millimeters, ensures the best conditions for the implantation of the blastocyst. Endometrium less than 7mm thick means low response to estrogen. Thin endometrium can make it difficult for the embryo to implant and develop, leading to implantation failure or early pregnancy loss. The process can be repeated 2-3 times with a response rate of 50-60%.
In our IVF Center after long experience of treating women with premature ovarian failure, DHEA has been administered with excellent results. Our excellent results have been published, in the prestigious medical journal of reproduction Fertility and Steriliy (2009). The worldwide acceptance was significant and already 165 authors refer to us in their research articles. So by combining the new technology of PRP with DHEA we can have better results.